Mechanistic Bacterial Immunology
We combine structural biology (cryo-EM) with biochemical, biophysical, kinetic and cellular approaches to understand how bacteria are able to rapidly identify and destroy predatory mobile genetic elements such as bacteriophage and plasmids.
Find out more about the work of Jack Bravo’s group here.
2.5 Å-resolution DdmDE handover complex structure, revealing how plasmids are targeted and licensed for elimination. (Bravo et al., Nature, 2024).
